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Huperzia saururus increases memory retention in rats

Summary citation from AGRICOLA, the online catalog of the National Agricultural Library (NAL)
 

Huperzia saururus increases memory retention in rats

Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids. On the basis of this information, a purified alkaloid extract was obtained by alkaline extraction of the aerial parts. The aim of this work was to investigate the effects of intra-hippocampal administration of the purified alkaloid extract (AE) on memory retention in vivo, using a step down test, in order to correlate with previous results obtained in vitro in an electrophysiological model. The AE administration significantly increased the latency time in comparison to control animals. For treated animals the latency time was 37.61 ± 2.84, 80.94 ± 2.37, and 180.00 ± 5.74 s for 1, 5, and 10 ng/rat, respectively versus 14.89 ± 2.38 s for controls. According to these results there is a good relationship between the ethnopharmacological use and the effects hereby showed.

Journal Title: Journal of ethnopharmacology.
Journal Volume/Issue: 2007 May 22, v. 111, issue 3
Main Author: Vallejo, M.G.
Other Authors: Ortega, M.G., Cabrera, J.L., Carlini, V.P., Rubiales de Barioglio, S., Agnese, A.M.
Format: Electronic
Language: English
Subjects: Huperzia
medicinal plants
chemical constituents of plants
alkaloids
plant extracts
medicinal properties
bioassays
rats
memory
ethnobotany
traditional medicine
herbal medicines
Argentina
Internet resource
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