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Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

Journal Title:
Proceedings of the National Academy of Sciences of the United States of America.
Journal Volume/Issue:
Feb 28, 1995. v. 92 (5)
Main Author:
Farese, R.V. Jr.
Other Authors:
Ruland, S.L., Flynn, L.M., Stokowski, R.P., and Young, S.G.
Format:
Article
Language:
English
Subjects:
diet
mice
structural genes
insertional mutagenesis
cells
mutants
embryogenesis
homozygosity
hypercholesterolemia
heterozygosity
cholesterol
animal models
blood lipids
lipoproteins
blood proteins
lethal genes
gene targeting
embryonic stem cells
high fat diet
apolipoproteins
View in NAL's Catalog:
IND20453080